To assess which antiepileptic medications (AEDs) he the best evidence for long-term efficacy or effectiveness as initial monotherapy for patients with newly diagnosed or untreated epilepsy.A 10-member subcommission of the Commission on Therapeutic Strategies of The International League Against Epilepsy (ILAE), including and pediatric epileptologists, clinical pharmacologists, clinical trialists, and a statistician evaluated ailable evidence found through a structured literature review including MEDLINE, Current Contents and the Cochrane Library for all applicable articles from 1940 until July 2005. Articles dealing with different seizure types (for different age groups) and two epilepsy syndromes were assessed for quality of evidence (four classes) based on predefined criteria. Criteria for class I classification were a double-blind randomized controlled trial (RCT) design, ≥48-week treatment duration without forced exit criteria, information on ≥24-week seizure freedom data (efficacy) or ≥48-week retention data (effectiveness), demonstration of superiority or 80% power to detect a ≤20% relative difference in efficacy/effectiveness versus an adequate comparator, and appropriate statistical ysis. Class II studies met all class I criteria except for hing either treatment duration of 24 to 47 weeks or, for noninferiority ysis, a power to only exclude a 21–30% relative difference. Class III studies included other randomized double-blind and open-label trials, and class IV included other forms of evidence (e.g., expert opinion, case reports). Quality of clinical trial evidence was used to determine the strength of the level of recommendation.
拍照离散地址
编辑: jiang下一页:癫痫病不会吃什么食物-
- 2022-05-02武汉不明原因肺炎临床表现公布!专家警告注意防控
- 2022-04-28癫痫的损害有哪些
- 2022-04-25适切癫痫的先兆研究
- 2022-04-21卒中后癫痫值得一提的是用药有哪些?解答卒中后癫痫的4大问题
- 2022-04-11基层注意,中药颗粒以后不能随意打开
- 2022-04-07箕星宣布aficamten在中国获得突破性治疗药物认定
- 综述:癫痫持续状态诊治最新进展
- 病例报告:水浴 PUVA 治疗皮下环状肉芽肿
- 基层注意,中药颗粒以后不能随意打开
- 婴儿身上的白斑是白癜风吗?
- 箕星宣布aficamten在中国获得突破性治疗药物认定
- 银屑病常用药物进入医疗保险,有效减轻患者的医疗负担
- JAMA:阳性结果的文章一定更受关注吗?
- PLoS ONE:新的合成蛋白能快速激活免疫系统抵抗流感
- BMJ:血浆置换对ANCA相关性血管炎患者的影响
- 原发性小肠淋巴管扩张症一例
- 癫痫治疗障碍仍难以克服
- 自身免疫病也可以免疫治疗
- 癫痫治疗 中医治疗癫痫不用担心
- 菟丝子的作用有哪些呢 菟丝子的功效与作用
- 乳腺癌的早期症状 预防乳腺癌的几种方法
- 什么时候容易得白癜风啊?不得不预防的白癜风频发时节
- Clin Gastroenterology?H:?多潘立酮治疗对胃轻瘫症状的影响
- 三庚酸酯可治疗1型转运体缺陷综合征
- 如何诊断最科学
- 病例分享:罕见的双眼孤立性脉络膜黑色素细胞增多
- 临床试验显示XenoPort 银屑病药物胃肠道副作用较严重
- 治疗白癜风的方法 牢记这些治疗白癜风更省钱
- 常见的癫痫病因有哪些?
- 20140115健康生活视频全集:丁健华谈到便秘的危害
- 白癜风到底该怎么治疗?
- 睡觉时突然抽搐 新生儿睡觉抽搐怎么办?
- 癫痫诊断的依据是什么?
- 男人的寿命与做这件事的频率有关
- 脑瘤一般多久才能治好 脑瘤病的治疗方法
- 癫痫病吃饱什么药好点
- 治疗癫痫病工具那个好
- 小学生课后发呆喊不醒 检查才知得了癫痫病
- 病症治疗 中医疗法治疗病症不用愁
- 癫痫病小猝死症状 这些症状就是癫痫小猝死
- 20120816cctv10生活品质之路:周文静揭秘脑部结构
- 癫痫病必需怎样来进行诊断
- 天使校园内:增加癫痫治疗的信心,这几个误区务必要知道!
- 青少年癫痫病怎么治疗最不可避免
- 癫痫病是什么原因逐步形成的
- 第九届 CAAE 国际癫痫论坛修持举行,中国抗癫痫事业开启新篇章